Endocrine Abstracts

Neurons in the hypothalamus play central roles in physiology and behavior, and their loss or dysfunction cause common human diseases such as obesity and the sleep disorder narcolepsy. Efforts to study these diseases have been hindered by the inaccessibility of human hypothalamic neurons. I developed a robust method to generate hypothalamic neurons from human embryonic and induced pluripotent stem cells. These stem cell-derived hypothalamic neurons include the AGRP and POMC neu...